Description
Flogodren capsules is a dietary supplement with effective anti-inflammatory and anti-edema action based on bromelain from pineapple, escin from horse chestnut and boswellia serrata resin. Bromelain is an enzyme with proteolytic activity extracted from the pineapple stem. It is absorbed in the intestine and has a marked anti-inflammatory and anti-edema action capable of reducing tissue edema and for this reason it is used to decongest soft tissues. (Post surgery, trauma, inflammatory joint diseases, bruises and sprains).
From the seeds, bark and leaves of horse chestnut, a mixture of saponins called escin is extracted, which has known medicinal properties. This phytocomplex contains several active molecules with proven anti-inflammatory action such as elucoside, and antioxidant action such as flavonoids and procyanidins. Escin increases the resistance of capillaries and reduces their permeability. It therefore exerts an anti-edema action, supported by the ability to intervene in local electrolyte exchange, favoring the removal of accumulated interstitial fluids. This capillarotropic and draining action, together with anti-inflammatory properties and a slight antithrombotic activity, make horse chestnut extracts standardized in escin indicated in the presence of disorders due to peripheral venous insufficiency (swelling, heaviness, pain, itching, etc.), varicose veins and post-phlebitic syndromes, hemorrhoids, cellulite, capillary fragility and edema.
Boswellia serrata, a plant rich in boswellic acid, is able to inhibit the enzyme 5-lipoxygenase responsible for the action of chronic inflammatory processes, to inhibit elastases, enzymes that attack the elastic part of tissues where an inflammatory process is underway, and to prevent the infiltration of polymorphonuclear cells that contribute to the destruction of connective tissue. It is used in the treatment of chronic inflammatory diseases with allergic immunological pathogenesis. Particularly indicated in inflammations of soft, muscle and joint tissues, but also of the gastrointestinal tract (Ulcerative colitis, Crohn's disease) and respiratory tract (anti-asthmatic activity).

Gluten-free (less than 20 ppm).

Directions for use
It is recommended to take 1 capsule per day unless otherwise advised by a doctor, away from meals.

Warnings
No side effects related to the use of the product are known; avoid in case of confirmed hypersensitivity to one or more components of the product. Keep out of reach of children under 3 years of age. Do not exceed the recommended daily doses. Supplements are not intended as substitutes for a varied, balanced diet and a healthy lifestyle.

Storage
Store in a cool, dry place, away from light and heat sources. Consume by the date indicated on the package. The expiry date refers to the product in intact packaging and correctly stored.
Shelf life in intact packaging: 36 months.

Format
Pack of 20 capsules of 550 mg.

Bibliography
1. Miller J and Opher A: The increased proteolytic activity of human blood serum after oral administration of Bromelain. Exp Med Surg 22, 277-280, 1964.
2. Izaka K,Yamada M, KawanoT, and SuyamaT: Gastrointestinal absorption and anti-inflammatory euect of Bromelain. Jpn J Pharmacol 22, 519-534, 1972.
3. Ganzera M, Khan IA. A reversed phase high performance liquid chromatography method for the analysis of boswellic acids in Boswellia serrata. Planta Med, 67(8):778-80, 2001.
4. Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti- inflammatory agent. Agents Actions, 18:407-12, 1986.
5. Indian Physiol Pharmacol. 201Oct-Dec;56(4):367-74. Anti-inflammatory euect of the serratiopeptidase- rationale or fashionable: a study in rat paw oedema model induced by the carrageenan.
6. Minerva Urol Nefrol. 2005 Mar;57(1):53-9. Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings].
7. Boll Chim Farm. 1985 Aug;124(8):71S-75S. Comparison between imidazole-2-hydroxybenzoate and serratio-peptidase in the treatment of phlogistic diseases of the respiratory tract].