Description
Food supplement based on Hericium, standardized to 50% polysaccharides and 20% beta(1,3-1,6)-D-glucans, from organic farming. Suitable for vegans, DNA certified, doping free.

Ingredients
Hericium erinaceus sporocarp*; vegetable capsule in hydroxypropylmethylcellulose.
*Organic ingredient.

Gluten-free.

Nutritional characteristics

Average values per 2 capsules
Hericium erinaceus (Bull.) Pers* sporocarp standardized powder 50% total polysaccharides 20% beta(1,3-1,6)-D-glucans	1,000 mg 500 mg 200 mg
Vegetable capsule in hydroxypropylmethylcellulose

Directions for use
Take 1 capsule twice a day with meals.

Warnings
Do not exceed the recommended daily dose.
Keep out of reach of children under 3 years of age.
Supplements are not intended as a substitute for a varied diet and should be used as part of a healthy and balanced lifestyle.

Storage
Store in a cool, dry place.
Validity with intact packaging: 36 months.

Format
Bottle containing 60 capsules of 0.600 g.
Net weight: 36 g.

Code. 0419

Bibliography
-Phan CW et al., Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways, Food Funct. 2014 Dec;5(12):3160-9.
-Lee KF et al., Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury- induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine, Int J Mol Sci. 2014 Aug 27;15 (9):15073-89.
-Jiang S et al., Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals, Appl Microbiol Biotechnol. 2014 Sep;98(18):7661-70.
-Zhu Y et al., Preparation, characterization, and anti-Helicobacter pylori activity of Bi3+-Hericium erinaceus polysaccharide complex, Carbohydr Polym. 2014 Sep 22;110:231.
-Xinyi Zan et al., Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis, International Journal of Biological Macromolecules, 2015, 76, 242-253. Liu Z, et al., Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium erinaceus(Higher Basidiomycetes) and Its Protective Effects on A-Triggered.
-Neurotoxicity in PC12 Cells, Int J Med Mushrooms. 2015;17(3):219-29.
-Zhang Yi et al., Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan- Induced Diabetic Neuropathic Pain in Rats, Evidence-Based Complementary and Alternative Medicine Volume 2015, Article ID 595480, 5 pages.
-Zan X et al., Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis, Int J Biol Macromol. 2015 May;76:242-53.
-Liu J et al., Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus., Exp Ther Med. 2015 Feb;9 (2):483-487.
-Wang K, et al., Erinacerins C-L, isoindolin-1-ones with-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus, J Nat Prod. 2015 Jan 23;78(1):146-54.
-Hou Y et al., Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus, Mol Med Rep. 2015 May;11(5):3794-9.
-Kobayashi H, et al., Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 from Hericium erinaceus on inhibition of human leukemia cell line proliferation., Biosci Biotechnol Biochem. 2015;79(2):211-7.