Description
Medical device based on Macrogol 4000 indicated for the treatment of chronic constipation; treatment of fecal impaction; treatment of constipation with episodic or chronic colic.
It is a laxative product that, thanks to its osmotic mechanism, regulates intestinal functions.
It is not absorbed, nor does it ferment in the intestine, it does not irritate the mucous membrane and is eliminated in the feces in an unchanged form. Thanks to its affinity for water, Macrostip* sachets soften stools, facilitating evacuation. Its action does not decrease over time.
*Patented formula.
Unflavored.

Ingredients
Macrogol 4000.

Gluten-free.
Lactose-free.

Nutritional characteristics

Average content	1 sachet
Macrogol 4,000	10 g

Directions for use
Adults, elderly and children aged 12 and over: 1 full-dose sachet (10 g) 1-3 times a day. Open the sachet along the dotted line and dilute the contents in 125 mL (approx. 1 glass of still water).
For prolonged use, the dose can be reduced to 1-2 sachets per day.
Children aged 7 to 11: half a sachet (5 g) twice a day. Dilute the contents in 62.5 mL (approx. half a glass of still water).
Children aged 3 to 6: half a sachet (5 g) once a day. Dilute the contents in 62.5 ml (approx. half a glass of still water).
Dissolve the contents of one sachet in a glass of water (125 ml). Drink the reconstituted solution.
The daily dose can be divided into several administrations. It is recommended to take Macrostip sachets away from meals.

Warnings
Do not take Macrostip sachets in case of known hypersensitivity to raw materials, gastrointestinal perforation and/or obstruction, known gastric or intestinal lesions, severe inflammatory bowel diseases such as Crohn's disease, ulcerative colitis and toxic megacolon.
No interactions with drugs are known, but it is advisable to take the product at least 2 hours apart from orally administered drugs, as the osmotic power of macrogol and the increased gastrointestinal transit speed induced can negatively affect their action. However, consult your doctor before taking Macrostip sachets if you are undergoing other therapies.
Macrostip sachets can potentially interact if used with starch-based food thickeners.
The macrogol ingredient counteracts the thickening effect of starch, thus liquefying preparations that need to remain thick for people with swallowing problems.
It is usually well tolerated because its mechanism of action is physical/mechanical and does not depend on systemic absorption. Undesirable effects such as indigestion, stomach ache or rumbling, bloating, flatulence, nausea, vomiting, anal irritation and mild diarrhea may occur during its intake. These effects improve by reducing the dose. In case of allergic reactions, stop taking it and contact your doctor. If any undesirable effect is found, inform your doctor or pharmacist.
Keep out of reach and sight of children. During pregnancy and breastfeeding, consult your doctor before taking the product. Use in children under 12 years of age should preferably be under medical supervision. Do not use Macrostip sachets for more than 30 consecutive days; if symptoms persist, consult your doctor. Avoid contact with eyes. Do not use the medical device beyond the expiry date. Do not use if the package is damaged. The treatment of fecal impaction requires prior medical advice.

Storage
Store the device tightly closed, in a cool and dry place, away from light and heat at a temperature not exceeding 25°C.
The expiry date is indicated on the package and on the sachet; it refers to the product in intact packaging, correctly stored.
The expired or to be disposed of device must be handled according to the waste management regulations of the competent local authority. Under no circumstances should the product or packaging be dispersed into the environment.
Shelf life in intact packaging: 24 months.

Format
Pack of 20 single sachets of 10 g.
Net weight: 200 g.