Description
Medical device useful for improving knee joint mobility, whose primary therapeutic treatment consists of the following functions:
1. Barrier effect.
2. Lubricating activity.
3. Mechanical support in case of ongoing pharmacological therapy.
The use of MD-KNEE is recommended for qualified healthcare professionals in private or public healthcare facilities for:
- improving knee mobility;
- promoting muscle relaxation;
- alleviating knee pain and projected pain during movement.

How to use
MD-KNEE can be used alone or in combination with other medical devices from the same line, to ensure a personalized treatment based on the individual clinical picture.
In cases where supportive treatment is required for acute pain, MD-KNEE can be combined with MD-NEURAL, MD-POLY, and MD-MUSCLE (one or more of these).
Furthermore, in cases where tissue matrix support therapy is required or a slowdown of physiological aging is necessary, MD-KNEE can be combined with MD-MATRIX and MD-TISSUE.

Therapeutic protocol:
1 treatment per week for 10 consecutive weeks.

Perarticular injectable administration (the application area must be aseptic; insert the needle to a depth of 2-4 mm).
For this use of the medical device, the following materials and accessories are recommended:
• Material to ensure skin asepsis: disposable glove, iodine-based solution, alcohol solution, sterile gauze, ethyl chloride-based skin spray.
• Needles: sterile 27 G.
• Syringes: 5 or 10 cc, depending on the quantity of solution to be injected.

Intra-articular injectable administration.
For this use of the medical device, the following materials and accessories are recommended:
• Material to ensure skin asepsis: disposable glove, iodine-based solution, alcohol solution, sterile gauze, ethyl chloride-based skin spray. It is recommended to apply a local anesthetic to the treated skin.
• Needles: sterile 22 G.
• Syringes: 2 cc, depending on the quantity of solution to be injected.

Intra-articular injection treatment (inner side):
The patient lies supine with the knee slightly flexed. Insert a 22 G needle towards the plane of the posterior surface of the patella in a medial and lateral position.

Components
Collagen of porcine origin.
Excipients: Arnica, NaCl, injectable water.

Warnings
Single-use.
No cases of hypersensitivity have been reported.
Contains collagen of animal origin from the porcine species. Patients with confirmed hypersensitivity to the component or excipients should first undergo an injection test in the arm and be kept under observation for one hour.
Knee pain requires differential diagnosis with collateral or cruciate ligament damage, prepatellar bursitis, hip pain pathologies, osteochondritis dissecans, arthropathy with a predominantly inflammatory character, gout, septic arthritis.
Slight redness in the injection area may be due to the mechanical effect of the needle or a skin reaction.
The application may cause burning/pain symptoms at the injection sites, which usually resolve within 5-10 minutes after the end of the treatment.
Skin cleansing/disinfection is necessary before and after application.
Any pyogenic bacteria could produce an abscess in the injection area.
Keep out of reach and sight of children.
Do not use after the expiry date.
Use the product immediately after opening.
Do not use if the seal is broken or tampered with.
After opening, the contents of the vial must be injected immediately.
Do not use if the packaging is damaged.

Storage
Store at a temperature between 2°C and 30°C, protect from sunlight and frost.
The expiry date refers to the product in intact packaging, correctly stored.

Format
Pack of 5 sterile 2 ml vials