ZERINOFEBB*AD 15TB 300+150MG

ZERINOFEBB 300 mg + 150 mg tablets
Paracetamol, sobrerol

What it is and what it is used for
ZERINOFEBB contains the active ingredients paracetamol and sobrerol. This medicine acts against fever and pain and as a fluidifier of secretions of the respiratory system.

ZERINOFEBB is used in adults for the treatment of symptoms of acute febrile respiratory disorders.

Contact your doctor if you do not feel better or if you feel worse after 3 days of treatment.

What you need to know before taking the medicine
Do not take ZERINOFEBB
- If you are allergic to paracetamol or sobrerol or any of the other ingredients of this medicine (listed in section 6);
- If you have a glucose-6-phosphate dehydrogenase deficiency (an inherited disease that leads to a decrease in red blood cell count);
- If you have one of the following diseases:
     - decreased red blood cell count (severe hemolytic anemia);
     - reduced liver function (severe hepatocellular insufficiency);
     - severe kidney function disorders;
     - severe blood cell disorders (blood dyscrasia).

Warnings and precautions
Talk to your doctor or pharmacist before taking ZERINOFEBB:
- if you have liver or kidney problems (hepatic or renal insufficiency), even if not severe;
- if you are being treated with blood thinners (anticoagulants), as in this case ZERINOFEBB should be administered at a reduced dosage (see Other medicines and ZERINOFEBB);
- if you have previously had sensitivity problems after taking acetylsalicylic acid (such as aspirin) and/or non-steroidal anti-inflammatory drugs (NSAIDs).

Do not use ZERINOFEBB outside the acute febrile phase and do not take the medicine for more than 3 consecutive days without consulting your doctor.

During treatment with ZERINOFEBB, before taking any other medicine, check that it does not contain paracetamol, as if paracetamol is taken in high doses, serious side effects may occur.
Furthermore, before combining any other medicine, contact your doctor (see also Other medicines and ZERINOFEBB).

High or prolonged doses of this medicine can cause kidney, blood cell (blood dyscrasia) and liver disorders, even severe ones.

Liver damage (hepatotoxicity) can occur with paracetamol even at prescribed doses, after short-term treatment, even in patients without a previous liver disease (see section Possible side effects).

Severe skin reactions: potentially fatal side effects such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis have been reported with the use of paracetamol. If you experience these disorders or any signs of one of these syndromes (e.g., progressive skin redness associated with blisters or mucous membrane lesions), immediately stop treatment with ZERINOFEBB and go to the nearest hospital.

Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you experience any of the following side effects, stop using ZERINOFEBB and contact your doctor immediately:
- rare very severe skin reactions such as toxic epidermal necrolysis, Stevens-Johnson syndrome and acute generalized exanthematous pustulosis (see section Warnings and precautions);
- allergic reactions (hypersensitivity) such as swelling of the skin, mucous membranes, larynx (angioedema), anaphylactic shock;
- skin irritations (erythema, urticaria, fixed drug eruption);
- decrease in the number of platelets (thrombocytopenia) and white blood cells (neutropenia, leukopenia);
- decrease in the number of white blood cells (agranulocytosis) and red blood cells (hemolytic anemia) in patients with a disease due to the lack of a substance called glucose 6-phosphate dehydrogenase;
- excess acid in the blood due to the presence of too much pyroglutamic acid resulting from low glutathione levels;
- impaired liver function and liver inflammation (hepatitis);
- destruction of liver cells (cytolytic hepatitis) which can lead to reduced liver function (acute liver failure);
- reduced kidney function (acute kidney failure), kidney inflammation (interstitial nephritis), blood in the urine (hematuria), lack of urine production (anuria);
- gastrointestinal disorders;
- dizziness;
- heart artery disorders of an allergic nature (Kounis syndrome);
- narrowing of the bronchi with difficulty breathing (bronchospasm).

Reporting of side effects
If you get any side effects, including any not listed in this leaflet, talk to your doctor or pharmacist. You can also report side effects directly via the national reporting system at: https://www.aifa.gov.it/content/segnalazionireazioni-avverse.
By reporting side effects, you can help provide more information on the safety of this medicine.