CLAREMA*CREAM 30G 1%

CLAREMA 1% cream
Heparan sulfate

What it is and what it is used for
CLAREMA contains the active ingredient heparan sulfate and is a medicine with antivaricose (against the formation of varicose veins) and vasoprotective (with a protective action on blood vessels) activity.

CLAREMA is used for the local treatment of:
- Phlebothrombosis (presence of blood clots inside the veins).
- Thrombophlebitis (inflammation of the veins with subsequent formation of blood clots).
- Venous ectasia (dilation of the veins) of the lower limbs.
- Skin conditions of vascular origin such as superficial periphlebitis (inflammation of the connective tissue surrounding the veins), inflammatory edema (accumulation of fluid due to inflammation), stasis dermatitis (superficial skin inflammation).
- Traumatic hematomas (accumulations of blood in an organ or tissue following trauma).
- Post-phlebitic pathology of the limbs (set of late clinical manifestations resulting from a thrombotic process that has affected the deep venous system of a limb).

What you need to know before taking the medicine
Do not use CLAREMA
- If you are allergic to the active ingredient (heparan sulfate) or any of the other ingredients of this medicine (listed in section 6).
- If you are allergic to heparin and heparinoids (drugs with anticoagulant action).
- In case of bleeding, on open wounds and mucous membranes, as well as on infection sites in case of suppurative processes (inflammation with pus production).

Warnings and precautions
Talk to your doctor or pharmacist before using CLAREMA.

The use of CLAREMA in the presence of hemorrhagic phenomena (blood loss from vessels) must be carefully evaluated.

Stop treatment immediately if sensitization phenomena (abnormal reactivity to the product) occur. The use, especially prolonged, of all products for topical (local) use can give rise to phenomena of this type (see section 4 Possible side effects).

Keep the medicine out of the sight and reach of children.

Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.

During treatment with CLAREMA, skin rashes and hives may occur. The frequency of these effects cannot be estimated as insufficient data are available.

The use, especially if prolonged, of products for topical use, can give rise to irritative and sensitization phenomena; in this event, interrupt the treatment and establish appropriate therapy (see Warnings and precautions).

Reporting of side effects
If you get any side effects, including any not listed in this leaflet, talk to your doctor or pharmacist. You can also report side effects directly via the national reporting system at: https://www.aifa.gov.it/content/segnalazionireazioni-avverse.
By reporting side effects you can help provide more information on the safety of this medicine.