Description
Biocompatible hydrogel of cross-linked sodium hyaluronate obtained through bio-fermentation and highly purified, dissolved in a physiological and isotonic buffer. The product is an injectable, sterile and pyrogen-free hydrogel, with a low endotoxin level.
JONEXA UP is formulated with highly purified sodium hyaluronate, salts of quality compliant with Pharmacopoeia requirements, and water for injections.
JONEXA UP reduces pain and increases the functionality of the affected joint.
JONEXA UP provides a lubricating and shock-absorbing effect on the affected joint.
JONEXA UP improves the patient's quality of life.
JONEXA UP must be administered by intra-articular injection by a qualified physician following all rules regarding aseptic procedure and injection technique.
JONEXA UP should be injected with a suitable sterile needle (18-21G needles are recommended).
It is recommended to administer JONEXA UP in a single session. The amount of product to be administered is at the discretion of the specialist physician. Discard any unused part of the syringe.

How to use
JONEXA UP should be injected into the joint in the synovial space of the knee, as a viscosupplementation for the synovial fluid, when the fluid's viscosity is reduced due to the osteoarthritis process, in patients who have not responded adequately to non-pharmacological conservative therapy and simple analgesics.
1. Before injection, the area to be treated must be thoroughly disinfected, and the product brought to room temperature.
2. Open the sterile packaging and remove the syringe from inside.
3. Remove the syringe cap without touching it, to keep it sterile.
4. Connect a suitable sterile needle (18-21G needles are recommended) to the syringe tip.
Ensure the needle is correctly locked onto the syringe's Luer-lock adapter before use.
5. Remove air from the syringe, if necessary.
6. Inject into the joint in the synovial space of the affected knee, following aseptic injection procedures.
7. At the end of the treatment session, discard the syringe and any remaining product.
The amount of product to be administered is at the discretion of the specialist physician; the recommended dose is 3-4 ml for each knee joint.

Components
Cross-linked sodium hyaluronate 20 mg/ml, disodium phosphate dodecahydrate 0.6 mg/ml, sodium dihydrogen phosphate dihydrate 0.05 mg/ml, sodium chloride 8 mg/ml, water for injections q.s.

Warnings
Do not administer JONEXA UP to patients with known hypersensitivity (allergy) to hyaluronic acid and/or other components of the product.
Do not administer JONEXA UP to patients with acute or chronic dermatological disorders or with inflammatory and/or infectious skin problems.
Do not administer JONEXA UP to patients with coagulation disorders and/or undergoing treatment with anticoagulant drugs.
JONEXA UP should not be administered to pregnant or breastfeeding women.
JONEXA UP should not be administered to children.
The use of JONEXA UP in any joint other than the knee and for other conditions has not been studied.
JONEXA UP must be strictly injected into the intra-articular space following aseptic injection procedures.
JONEXA UP must be administered with sterile Luer-lock needles.
Do not inject into a blood vessel or surrounding tissues. To avoid pain after injection, it is recommended to keep the local injection site still.
The product must not be used if the packaging is damaged or broken.
The product must not be used after the expiration date.
The product is for single-use only. Do not reuse; risk of infection.
Do not re-sterilize; re-sterilization may affect the physical-chemical properties of the product and compromise its efficacy and safety.
The syringe and used needle must be disposed of in a proper container.
Keep out of reach of children.
Do not use with other products containing quaternary ammonium salts such as benzalkonium chloride or with any surgical material treated with this type of substance, as sodium hyaluronate may precipitate in their presence. To prevent any possible interaction, avoid concomitant administration with other intra-articular products.
No interactions with other local anesthetics are known.

Storage
Store between 5 °C and 25 °C. Protect from light and avoid freezing.
Do not use after the date indicated on the packaging.

Format
4.4 ml syringe.

Cod. 6801