PSORADIN

Food supplement based on Omega 3, vitamins and mineral salts to be used as an adjuvant in certain pathological conditions such as psoriasis.
In patients suffering from psoriasis, the administration of Omega 3 (alpha-linolenic acid, EPA, DHA) in conjunction with standard topical and/or systemic treatments, is able to:
- Decrease the production of pro-inflammatory cytokines. (1,4)
- Lead to a significant improvement in total PASI. (1)
- Extend the benefits of phototherapy. (6)
- Reduce the nephrotoxicity of Cyclosporine. (6)
- Reduce hyperlipidemia induced by the use of systemic retinoids. (6)
Vitamins A and D
They are able to inhibit keratinocyte proliferation and stimulate the differentiation of immature ones. (7)
Vitamin E
With antioxidant and free radical scavenging action, particularly high in all chronic inflammatory processes. (8)
Zinc, Selenium, and Chromium
Components of important enzymatic complexes essential for maintaining normal skin and immune system functions. (9)
Useful for all patients with psoriasis or psoriatic arthritis, whether undergoing topical and/or systemic therapies, or untreated.

Ingredients
Flaxseed oil (linum usitatissimum); concentrated fish oil; edible gelatin; firming agent: glycerol; thickener: colloidal silica; zinc gluconate; dl-alpha-tocopheryl acetate (vitamin E acetate); anti-caking agent: E555; Vitamin A palmitate 1 M UI/g (Retinol in sunflower oil); chromium chloride; vitamin D3 1M UI/g (Cholecalciferol in medium chain triglycerides); sodium selenite; colorings: E172.

Directions for use
Take 2 capsules daily.

Warnings
Do not exceed the recommended daily dose.
Keep out of reach of children under 3 years of age.
Supplements should not be considered as substitutes for a varied diet.
For pregnant or breastfeeding women and children, it is recommended to consult a doctor.

Storage
Store in a cool, dry place, away from light and heat sources.

Nutritional characteristics

	per 2 capsules	%RDA*
Energy value	16.814 kcal 69.530 kj
Proteins	0.472 g	-
Carbohydrates	0.240 g	-
Fats of which: Saturated fatty acids Monounsaturated fatty acids Polyunsaturated fatty acids of which Alpha-linolenic acid EPA DHA Omega 3	1.552 g 0.060 g 0.102 g 1.372 g 0.600 g 0.282 0.188 g 1.100 g
Vitamin E	10 mg-á-TE	83.3
Vitamin A	800 mcg-RE	100
Vitamin D	5 mcg	100
Zinc	11.25 mg	112.5
Chromium	150 mcg	375
Selenium	75 mcg	136.4
Flaxseed oil	0.858 g
Fish oil	0.694 g

*RDA: recommended daily allowance.

Format
Pack of 45 capsules.

Bibliography
  -   1 Mayser P., et All. “n-3 fatty acid in psoriasis”, Br. J. Nutr. 2002, Jan;87 Suppl 1:S77-82 2 - Staberg et all. “Abnormal vitamin D metabolism in patients with psoriasis”. Acta Derm Venereol. 1987;67(1) 65-68.
  -   3 McMillan et all. “ Plasma zinc in psoriasis:relation to surface area involvement” Br.J.Dermatol. 1983;108 (3):301-305 4 - Artemis P. et all. “Omega 3 fatty acids in inflammation and autoimmune diseases”. J.Am. College of Nutr. Vol. 21 n° 6 , 495-505 (2002).
  -   5 Simopoulos AP. “The omega 6/omega 3 fatty acid ratio, genetic variation and cardiovascular disease”.Asia Pac. J. Clin. Nutr.,2008; 17 suppl. 1:131-134.
  -   6 Simopoulos AP. “Omega 3 fatty acids in health and disease and in growth and development”. Am. J. Clin. Nutr. 1991;54:438-463.
  -   7 Lehmann B. et all.” Vitamin D and skin: new aspects for dermatology”. Exp. Dermatol. 2004; 13 suppl. 4:11-15.
  -   8 Corrocher et all.”Effect of fish oil supplementation on erythrocyte lipid pattern in psoriasis” Clin. Chim. Acta, 1989, Feb. 15;179(2):121-131.
  -   9 Maggini et all.”Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune response”. Br. J. Nutr. 2007 Oct; 98 Suppl. 1:s29-35.