Description
Food supplement with plant-derived vitamins D3 and K2 in sunflower seed oil. With lemon and orange essential oils. The product is indicated to promote bone mineralization by enhancing calcium and phosphorus absorption/utilization. It is therefore effective in improving post-menopausal osteoporosis by improving bone density and reducing the risk of fractures. It also has beneficial effects on muscle contraction and trophism, in addition to stimulating the immune system.

Ingredients
Sunflower seed oil, vitamin D (cholecalciferol) extracted from lichen [Cladonia rangiferina (L.) Weber ex F.H. Wigg.], vitamin K2 (menaquinone-7); antioxidant: alpha-tocopherol; orange (Citrus aurantium var. dulcis Hayne) essential oil, lemon [Citrus limon (L.) Osbeck.] essential oil.

Nutritional characteristics

Average values	Per 12 drops equal to 0.5 ml
Vitamin D3 from lichen	50 mcg (1,000% NRV*)
Vitamin K2 (menaquinone-7)	25 mcg (33% NRV*)
Lemon e.o.	0.2 mg
Orange e.o.	0.2 mg

*NRV: Nutrient Reference Values.

Instructions for use
-Adults: a maximum of 12 drops per day is recommended.
-Adolescents and pregnant women: a maximum of 6 drops per day is recommended.
-Children aged 3 and above: a maximum of 3 drops per day is recommended.

Warnings
Do not exceed the recommended daily dose. Keep out of reach of children under 3 years of age. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Interactions or side effects: vitamin K is known to interact with anticoagulant drugs.

Storage
Store tightly closed in a cool, dry place, away from light. The expiry date refers to the product stored correctly, in an unopened package.

Format
Capacity: 30 ml.

Bibliography
1. AA.VV. - PDR Integratori Nutrizionali, CEC Editore, Milano, 2003.
2. Vanherwegen AS, Gysemans C, Mathieu C. (2017) Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am.
3. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. (2010) Vitamin D: modulator of the immune system. Curr Opin Pharmacol.
4. Aranow, Cynthia. (2011) Vitamin D and the immune system. Journal of investigative medicine: the official publication of the American Federation for Clinical Research vol. 59,6: 881-6. doi: 10.2310/JIM.0b013e31821b8755
5. Simes DC, Viegas CSB, Araújo N, Marreiros C. (2019) Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci.A. Spiro and J. L. Buttriss, (2014) Vitamin D: an overview of vitamin D status and intake in Europe, Nutrition Bulletin, vol. 39, pp. 322-350.
6. J. C. Fleet, (2017) The role of vitamin D in the endocrinology controlling calcium homeostasis, Molecular and Cellular Endocrinology, vol. 17, pp. 30221-30226.
7. Adriana J. van Ballegooijen et al (2007) The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review International Journal of Endocrinology.
8. Beulens J et al (2013) The role of menaquinones (vitamin K2) in human health. Br J Nutr 110(8):1357-1368.
9. Maresz K (2015) Proper calcium use: Vitamin K2 as a promoter of bone and cardiovascular health. Integr Health 14(1):34-39.
10.Ikeda Y et al (2006) Intake of Fermented Soybeans, Natto, Is Associated with Reduced Bone Loss in Postmenopausal Women: Japanese Population-Based Osteoporosis (JPOS) Study.J Nutr 136(5):1323-1328.
11.Inaba N et al (2015) Low-Dose Daily Intake of Vitamin K2 (Menaquinone-7) Improves Osteocalcin ?- Carboxylation: A Double- Blind, Randomized Controlled Trial. J Nutr Sci Vitaminol (Tokyo) 61(6):471- 480.
12.Knapen M et al (2013) Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis Int 24(9):2499-2507.
13.Geleijnse J et al (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam study.