ZEFLAVON*60 COATED TABS 500MG

ZEFLAVON 500 mg film-coated tablets
micronized flavonoids, such as diosmin and other flavonoids expressed as hesperidin

What it is and what it is used for
Zeflavon is a vasoprotector. It increases venous tone and the resistance of small blood vessels.

Zeflavon is indicated in adults:
- for the treatment of symptoms related to chronic venous insufficiency of the lower limbs: heavy legs, leg swelling, pain, nocturnal leg cramps (pain that occurs in the legs at night);
- for the treatment of functional symptoms related to acute hemorrhoidal attacks, such as pain, bleeding, and swelling in the anal region.

What you need to know before taking the medicine
Do not take Zeflavon:
- if you are allergic to the active ingredients or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions
Talk to your doctor or pharmacist before taking Zeflavon.

Chronic venous disease:
In case of venous insufficiency, treatment should be combined with a healthy lifestyle to achieve the best results. Avoid sun exposure, heat, standing for long periods, or being overweight. Walking and wearing special (compression) stockings improves circulation.

If your condition worsens during treatment, manifesting as skin or vein inflammation, hardening of subcutaneous tissue, severe pain, skin ulcers, or atypical symptoms such as sudden swelling of one or both legs, tell your doctor immediately.

Zeflavon does not help reduce swelling of the lower limbs if it is caused by heart, kidney, or liver disease.

Acute hemorrhoidal disease:
If you have an acute hemorrhoid attack, you can take Zeflavon for a limited period of 7 days only. If the symptoms of the acute hemorrhoidal attack do not disappear within 7 days, talk to your doctor.

If the condition worsens during treatment, i.e., if you notice increased rectal bleeding, blood in your stools, or have doubts about hemorrhoidal bleeding, consult your doctor.

Treatment with Zeflavon does not replace specific treatment for other anal disorders.

If you have any questions, ask your doctor or pharmacist.

Children and adolescents
Zeflavon is not recommended for use in children and adolescents.

Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.

Common: may affect up to 1 in 10 people
Nausea, vomiting, diarrhea, dyspepsia.

Uncommon: may affect up to 1 in 100 people
Colon inflammation.

Rare: may affect up to 1 in 1,000 people
Headache, dizziness, malaise, rash, itching, hives.

Not known: frequency cannot be estimated from the available data
- Isolated edema of the face, lips, or eyelids in association with allergic symptoms.
Exceptionally, Quincke's edema (rapidly developing edema of the face, lips, mouth, tongue, or pharynx, which may be accompanied by difficulty breathing) may develop.
- Abdominal pain.

Reporting of side effects
If you get any side effects, including any not listed in this leaflet, talk to your doctor or pharmacist. You can also report side effects directly via the national reporting system at: https://www.aifa.gov.it/content/segnalazionireazioni-avverse.
By reporting side effects, you can help provide more information on the safety of this medicine.